Agonist trapped in ATP-binding sites of the P2X2 receptor

ATP-gated P2X receptors are trimeric ion channels, as recently confirmed by X-ray crystallography. However, the structure was solved without ATP and even though extracellular intersubunit cavities surrounded by conserved amino acid residues previously shown to be important for ATP function were prop...

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Bibliographic Details
Main Authors: Jiang, Ruotian, Lemoine, Damien, Martz, Adeline, Taly, Antoine, Gonin, Sophie, Prado de Carvalho, Lia, Specht, Alexandre, Grutter, Thomas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107266/
https://ncbi.nlm.nih.gov/pubmed/21576497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102170108
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