Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel

P2X receptors function by opening a transmembrane pore in response to extracellular ATP. Recent crystal structures solved in apo and ATP-bound states revealed molecular motions of the extracellular domain following agonist binding. However, the mechanism of pore opening still remains controversial....

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Habermacher, Chloé, Martz, Adeline, Calimet, Nicolas, Lemoine, Damien, Peverini, Laurie, Specht, Alexandre, Cecchini, Marco, Grutter, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739762/
https://ncbi.nlm.nih.gov/pubmed/26808983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11050
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