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Inorganic polyphosphate is a potent activator of the mitochondrial permeability transition pore in cardiac myocytes
Mitochondrial dysfunction caused by excessive Ca(2+) accumulation is a major contributor to cardiac cell and tissue damage during myocardial infarction and ischemia–reperfusion injury (IRI). At the molecular level, mitochondrial dysfunction is induced by Ca(2+)-dependent opening of the mitochondrial...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3343371/ https://ncbi.nlm.nih.gov/pubmed/22547663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210788 |
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