Asymmetric Mode of Ca(2+)-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling

Filament assembly of nonmuscle myosin IIA (NMIIA) is selectively regulated by the small Ca(2+)-binding protein, S100A4, which causes enhanced cell migration and metastasis in certain cancers. Our NMR structure shows that an S100A4 dimer binds to a single myosin heavy chain in an asymmetrical configu...

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Detalhes bibliográficos
Main Authors: Elliott, Paul R., Irvine, Andrew F., Jung, Hyun Suk, Tozawa, Kaeko, Pastok, Martyna W., Picone, Remigio, Badyal, Sandip K., Basran, Jaswir, Rudland, Philip S., Barraclough, Roger, Lian, Lu-Yun, Bagshaw, Clive R., Kriajevska, Marina, Barsukov, Igor L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343272/
https://ncbi.nlm.nih.gov/pubmed/22483112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.02.002
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