Mechanism of the Ca(2+)-Dependent Interaction between S100A4 and Tail Fragments of Nonmuscle Myosin Heavy Chain IIA

The interaction between the calcium-binding protein S100A4 and the C-terminal fragments of nonmuscle myosin heavy chain IIA has been studied by equilibrium and kinetic methods. Using site-directed mutants, we conclude that Ca(2+) binds to the EF2 domain of S100A4 with micromolar affinity and that th...

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Main Authors: Badyal, Sandip K., Basran, Jaswir, Bhanji, Nina, Kim, Ju Hwan, Chavda, Alap P., Jung, Hyun Suk, Craig, Roger, Elliott, Paul R., Irvine, Andrew F., Barsukov, Igor L., Kriajevska, Marina, Bagshaw, Clive R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025356/
https://ncbi.nlm.nih.gov/pubmed/21110983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.11.036
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