Regulated Proteolysis of Nonmuscle Myosin IIA Stimulates Osteoclast Fusion

The nonmuscle myosin IIA heavy chain (Myh9) is strongly associated with adhesion structures of osteoclasts. In this study, we demonstrate that during osteoclastogenesis, myosin IIA heavy chain levels are temporarily suppressed, an event that stimulates the onset of cell fusion. This suppression is n...

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Bibliografiske detaljer
Main Authors: McMichael, Brooke K., Wysolmerski, Robert B., Lee, Beth S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Molecular Basis of Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673295/
https://ncbi.nlm.nih.gov/pubmed/19269977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808621200
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