Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis

Hypoxia-inducible factor (HIF), a key modulator of the transcriptional response to hypoxia, is increased in colon cancer. However, the role of HIF in colon carcinogenesis in vivo remains unclear. In this study, we found that intestinal epithelium-specific disruption of the von Hippel-Lindau tumor su...

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Autori principali: Xue, Xiang, Taylor, Matthew, Anderson, Erik, Hao, Cathy, Qu, Aijuan, Greenson, Joel K., Zimmermann, Ellen M., Gonzalez, Frank J., Shah, Yatrik M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342485/
https://ncbi.nlm.nih.gov/pubmed/22419665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3836
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