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Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis

Hypoxia-inducible factor (HIF), a key modulator of the transcriptional response to hypoxia, is increased in colon cancer. However, the role of HIF in colon carcinogenesis in vivo remains unclear. In this study, we found that intestinal epithelium-specific disruption of the von Hippel-Lindau tumor su...

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Bibliografiske detaljer
Main Authors: Xue, Xiang, Taylor, Matthew, Anderson, Erik, Hao, Cathy, Qu, Aijuan, Greenson, Joel K., Zimmermann, Ellen M., Gonzalez, Frank J., Shah, Yatrik M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342485/
https://ncbi.nlm.nih.gov/pubmed/22419665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3836
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