Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo.

Subsequent to the discovery that RNA can have site specific cleavage activity, there has been a great deal of interest in the design and testing of trans-acting catalytic RNAs as both surrogate genetic tools and as therapeutic agents. We have been developing catalytic RNAs or ribozymes with target s...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Taylor, N R, Kaplan, B E, Swiderski, P, Li, H, Rossi, J J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1992
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334185/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1408757/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.17.4559
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