Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo.
Subsequent to the discovery that RNA can have site specific cleavage activity, there has been a great deal of interest in the design and testing of trans-acting catalytic RNAs as both surrogate genetic tools and as therapeutic agents. We have been developing catalytic RNAs or ribozymes with target s...
Shranjeno v:
| izdano v: | Nucleic Acids Res |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
1992
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| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334185/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1408757/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.17.4559 |
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