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Physicochemical Characterization of the Catalytic Unit of Hammerhead Ribozyme and Its Relationship with the Catalytic Activity

The catalytic mechanism of hammerhead ribozymes (HHRzs) attracted great attention in relation to the chemical origin of life. However, the basicity (p<i>K</i><sub>a</sub>) of the catalytic sites of HHRzs has not been studied so far. As a result, the investigation of the currently assumed mechanism f...

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Principais autores: Yoshiyuki Tanaka, Daichi Yamanaka, Saori Morioka, Taishi Yamaguchi, Masayuki Morikawa, Takashi S. Kodama, Vladimír Sychrovský, Chojiro Kojima, Yoshikazu Hattori
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-08-01
coleção:Biophysica
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Acesso em linha:https://www.mdpi.com/2673-4125/2/3/22
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