An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions.

Synthetic c-Ha-ras genes with an analogue of an abasic site in the first or the second position of codon 12, or in the second position of codon 61 were constructed and transfected into NIH3T3 cells. The genes with the lesions in codon 12 exhibited more focus formation than a normal c-Ha-ras gene, wh...

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Bibliographic Details
Main Authors: Kamiya, H, Suzuki, M, Komatsu, Y, Miura, H, Kikuchi, K, Sakaguchi, T, Murata, N, Masutani, C, Hanaoka, F, Ohtsuka, E
Format: Artigo
Language:Inglês
Published: 1992
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC334165/
https://ncbi.nlm.nih.gov/pubmed/1408742
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