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Transforming Activity of a Synthetic c‐Ha‐ras Gene Containing O(6)‐Methylguanine in Codon 12
A mutagenic DNA‐adduct, O(6)‐methylguanine, was introduced into codon 12 of the synthetic c‐Ha‐ras gene by cassette mutagenesis. Transfection of this modified ras gene into normal NIH3T3 cells by the calcium phosphate procedure resulted in significant induction of focus formation. The ras gene inser...
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| Publicado no: | Jpn J Cancer Res |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5918606/ https://ncbi.nlm.nih.gov/pubmed/1938604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1991.tb01934.x |
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