Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons

Recent studies have shown the involvement of cyclin-dependent kinase 5 (Cdk5) in cell cycle regulation in postmitotic neurons. In this study, we demonstrate that Cdk5 and its co-activator p35 were detected in the nuclear fraction in neurons and Cdk5/p35 phosphorylated retinoblastoma (Rb) protein, a...

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Hlavní autoři: Futatsugi, Akira, Utreras, Elias, Rudrabhatla, Parvathi, Jaffe, Howard, Pant, Harish C., Kulkarni, Ashok B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341229/
https://ncbi.nlm.nih.gov/pubmed/22456337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20009
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