Tumor Necrosis Factor-α Regulates Cyclin-dependent Kinase 5 Activity during Pain Signaling through Transcriptional Activation of p35

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase. We have previously reported that Cdk5 participates in the regulation of nociceptive signaling, and the expression of Cdk5 and its activator, p35, are up-regulated in nociceptive neurons during peripheral inflammation. Th...

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Bibliografiske detaljer
Main Authors: Utreras, Elias, Futatsugi, Akira, Rudrabhatla, Parvathi, Keller, Jason, Iadarola, Michael J., Pant, Harish C., Kulkarni, Ashok B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629110/
https://ncbi.nlm.nih.gov/pubmed/19049962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805052200
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