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Enhancing CHK1 inhibitor lethality in glioblastoma

The present studies were initiated to determine whether inhibitors of MEK1/2 or SRC signaling, respectively, enhance CHK1 inhibitor lethality in primary human glioblastoma cells. Multiple MEK1/2 inhibitors (CI-1040 (PD184352); AZD6244 (ARRY-142886)) interacted with multiple CHK1 inhibitors (UCN-01,...

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Bibliografiske detaljer
Main Authors: Tang, Yong, Dai, Yun, Grant, Steven, Dent, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341214/
https://ncbi.nlm.nih.gov/pubmed/22313687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.19240
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