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Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson’s disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression

Alternative splicing is a complex post-transcriptional process that can be regulated by cis-acting elements located within genomic non-coding regions. Recent studies have identified that polymorphic variations in non-coding regions of the α-synuclein gene (SNCA) locus are associated with an increase...

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Main Authors: McLean, Jesse R., Hallett, Penelope J., Cooper, Oliver, Stanley, Michael, Isacson, Ole
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340908/
https://ncbi.nlm.nih.gov/pubmed/22155155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2011.11.006
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