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Polyglutamine Neurodegeneration: Expanded Glutamines Enhance Native Functions
An intriguing set of neurodegenerative disease are the nine disorders caused by the expansion of a unstable trinucleotide CAG repeat where the repeat is located within the coding of the affected gene, i.e. the polyglutamine (polyQ) diseases. A gain-of-function mechanism for toxicity in polyQ disease...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340441/ https://ncbi.nlm.nih.gov/pubmed/22284692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2012.01.001 |
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