Disruption of Proprotein Convertase 1/3 (PC1/3) Expression in Mice Causes Innate Immune Defects and Uncontrolled Cytokine Secretion

The proprotein convertase 1/3 is expressed in the regulated secretory pathway of neural and endocrine cells. Its major function is in the post-translational processing and activation of precursor proteins. The PC1/3 knock-out (KO) mouse model has allowed us to elucidate its physiological functions i...

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Autores principales: Refaie, Sarah, Gagnon, Sandra, Gagnon, Hugo, Desjardins, Roxane, D'Anjou, François, D'Orléans-Juste, Pedro, Zhu, Xiaorong, Steiner, Donald F., Seidah, Nabil G., Lazure, Claude, Salzet, Michel, Day, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340273/
https://ncbi.nlm.nih.gov/pubmed/22396549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.323220
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