Phosphorylation by Protein Kinase Cα Regulates RalB Small GTPase Protein Activation, Subcellular Localization, and Effector Utilization

Ras-like (Ral) small GTPases are regulated downstream of Ras and the noncanonical Ral guanine nucleotide exchange factor (RalGEF) effector pathway. Despite RalA and RalB sharing 82% sequence identity and utilization of shared effector proteins, their roles in normal and neoplastic cell growth have b...

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Autors principals: Martin, Timothy D., Mitin, Natalia, Cox, Adrienne D., Yeh, Jen Jen, Der, Channing J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340265/
https://ncbi.nlm.nih.gov/pubmed/22393054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344986
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