Peptides from Second Extracellular Loop of C-C Chemokine Receptor Type 5 (CCR5) Inhibit Diverse Strains of HIV-1

To initiate HIV entry, the HIV envelope protein gp120 must engage its primary receptor CD4 and a coreceptor CCR5 or CXCR4. In the absence of a high resolution structure of a gp120-coreceptor complex, biochemical studies of CCR5 have revealed the importance of its N terminus and second extracellular...

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Main Authors: Dogo-Isonagie, Cajetan, Lam, Son, Gustchina, Elena, Acharya, Priyamvada, Yang, Yongping, Shahzad-ul-Hussan, Syed, Clore, G. Marius, Kwong, Peter D., Bewley, Carole A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
Protein Structure and Folding
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340262/
https://ncbi.nlm.nih.gov/pubmed/22403408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.332361
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