p38γ Mitogen-activated Protein Kinase (MAPK) Confers Breast Cancer Hormone Sensitivity by Switching Estrogen Receptor (ER) Signaling from Classical to Nonclassical Pathway via Stimulating ER Phosphorylation and c-Jun Transcription

Estrogen receptor (ER) α promotes breast cancer growth by regulating gene expression through classical estrogen response element (ERE) binding and nonclassical (interaction with c-Jun at AP-1 sites) pathways. ER is the target for anti-estrogens such as tamoxifen (TAM). However, the potential for cla...

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Hlavní autoři: Qi, Xiaomei, Zhi, Huiying, Lepp, Adrienne, Wang, Phillip, Huang, Jian, Basir, Zainab, Chitambar, Christopher R., Myers, Charles R., Chen, Guan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340246/
https://ncbi.nlm.nih.gov/pubmed/22399296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.349357
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