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Structural and Functional Characterization of Monomeric EphrinA1 Binding Site to EphA2 Receptor

The EphA2 receptor is overexpressed in glioblastoma multiforme and has been to shown to contribute to cell transformation, tumor initiation, progression, and maintenance. EphrinA1 (eA1) is a preferred ligand for the receptor. Treatment with monomeric eA1, the form of eA1 found in the extracellular e...

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Main Authors: Lema Tomé, Carla M., Palma, Enzo, Ferluga, Sara, Lowther, W. Todd, Hantgan, Roy, Wykosky, Jill, Debinski, Waldemar
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340174/
https://ncbi.nlm.nih.gov/pubmed/22362770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311670
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