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Frequent Incorporation of Ribonucleotides during HIV-1 Reverse Transcription and Their Attenuated Repair in Macrophages

Macrophages are well known long-lived reservoirs of HIV-1. Unlike activated CD4(+) T cells, this nondividing HIV-1 target cell type contains a very low level of the deoxynucleoside triphosphates (dNTPs) required for proviral DNA synthesis whereas the ribonucleoside triphosphate (rNTP) levels remain...

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書目詳細資料
Main Authors: Kennedy, Edward M., Amie, Sarah M., Bambara, Robert A., Kim, Baek
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340154/
https://ncbi.nlm.nih.gov/pubmed/22383524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348482
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