ESR spectroscopy identifies inhibitory Cu(2+) sites in a DNA-modifying enzyme to reveal determinants of catalytic specificity

The relationship between DNA sequence recognition and catalytic specificity in a DNA-modifying enzyme was explored using paramagnetic Cu(2+) ions as probes for ESR spectroscopic and biochemical studies. Electron spin echo envelope modulation spectroscopy establishes that Cu(2+) coordinates to histid...

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Hlavní autoři: Yang, Zhongyu, Kurpiewski, Michael R., Ji, Ming, Townsend, Jacque E., Mehta, Preeti, Jen-Jacobson, Linda, Saxena, Sunil
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340070/
https://ncbi.nlm.nih.gov/pubmed/22493217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200733109
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