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ESR spectroscopy identifies inhibitory Cu(2+) sites in a DNA-modifying enzyme to reveal determinants of catalytic specificity
The relationship between DNA sequence recognition and catalytic specificity in a DNA-modifying enzyme was explored using paramagnetic Cu(2+) ions as probes for ESR spectroscopic and biochemical studies. Electron spin echo envelope modulation spectroscopy establishes that Cu(2+) coordinates to histid...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340070/ https://ncbi.nlm.nih.gov/pubmed/22493217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200733109 |
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