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Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
The study of proteolysis lies at the heart of our understanding of biocatalysis, enzyme evolution, and drug development. To understand the degree of natural variation in protease active sites, we systematically evaluated simple active site features from all serine, cysteine and threonine proteases o...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581919/ https://ncbi.nlm.nih.gov/pubmed/23382230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221050110 |
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