Aminoglycoside 2′′-Phosphotransferase IIIa (APH(2′′)-IIIa) Prefers GTP over ATP: STRUCTURAL TEMPLATES FOR NUCLEOTIDE RECOGNITION IN THE BACTERIAL AMINOGLYCOSIDE-2′′ KINASES

Contrary to the accepted dogma that ATP is the canonical phosphate donor in aminoglycoside kinases and protein kinases, it was recently demonstrated that all members of the bacterial aminoglycoside 2′′-phosphotransferase IIIa (APH(2′′)) aminoglycoside kinase family are unique in their ability to uti...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Smith, Clyde A., Toth, Marta, Frase, Hilary, Byrnes, Laura J., Vakulenko, Sergei B.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2012
الموضوعات:
Protein Structure and Folding
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339938/
https://ncbi.nlm.nih.gov/pubmed/22367198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341206
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