Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

The Rho GTPase Rac regulates actin cytoskeleton reorganization to form cell surface extensions (lamellipodia) required for cell migration/invasion during cancer metastasis. Rac hyperactivation and overexpression are associated with aggressive cancers; thus, interference of the interaction of Rac wit...

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Autori principali: Montalvo-Ortiz, Brenda L., Castillo-Pichardo, Linette, Hernández, Eliud, Humphries-Bickley, Tessa, De La Mota-Peynado, Alina, Cubano, Luis A., Vlaar, Cornelis P., Dharmawardhane, Suranganie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339933/
https://ncbi.nlm.nih.gov/pubmed/22383527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334524
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