Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie

In transmissible spongiform encephalopathies (TSEs) and Alzheimer disease (AD) both misfolding and aggregation of specific proteins represent key features. Recently, it was observed that PrP(C) is a mediator of a synaptic dysfunction induced by Aβ oligomers. We tested a novel γ-secretase modulator (...

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Détails bibliographiques
Auteurs principaux: Poli, Giorgio, Corda, Erica, Lucchini, Barbara, Puricelli, Maria, Martino, Piera Anna, Dall'Ara, Paola, Villetti, Gino, Bareggi, Silvio R, Corona, Cristiano, Costassa, Elena Vallino, Gazzuola, Paola, Iulini, Barbara, Mazza, Maria, Acutis, Pierluigi, Mantegazza, Paolo, Casalone, Cristina, Imbimbo, Bruno P
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2012
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338967/
https://ncbi.nlm.nih.gov/pubmed/22453180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.6.1.18317
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