CHF5074, a novel γ-secretase modulator, attenuates brain β-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease

BACKGROUND AND PURPOSE: We evaluated the effects of 1-(3′,4′-dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a new γ-secretase modulator, on brain β-amyloid pathology and spatial memory in transgenic mice expressing the Swedish and London mutations of human amyloid prec...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Imbimbo, BP, Hutter-Paier, B, Villetti, G, Facchinetti, F, Cenacchi, V, Volta, R, Lanzillotta, A, Pizzi, M, Windisch, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697723/
https://ncbi.nlm.nih.gov/pubmed/19239474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00097.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados