CHF5074, a novel γ-secretase modulator, attenuates brain β-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease

BACKGROUND AND PURPOSE: We evaluated the effects of 1-(3′,4′-dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a new γ-secretase modulator, on brain β-amyloid pathology and spatial memory in transgenic mice expressing the Swedish and London mutations of human amyloid prec...

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Autors principals: Imbimbo, BP, Hutter-Paier, B, Villetti, G, Facchinetti, F, Cenacchi, V, Volta, R, Lanzillotta, A, Pizzi, M, Windisch, M
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2009
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697723/
https://ncbi.nlm.nih.gov/pubmed/19239474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00097.x
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