Antibody Repertoires in Humanized NOD-scid-IL2Rγ(null) Mice and Human B Cells Reveals Human-Like Diversification and Tolerance Checkpoints in the Mouse

Immunodeficient mice reconstituted with human hematopoietic stem cells enable the in vivo study of human hematopoiesis. In particular, NOD-scid-IL2Rγ(null) engrafted mice have been shown to have reasonable levels of T and B cell repopulation and can mount T-cell dependent responses; however, antigen...

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Main Authors: Ippolito, Gregory C., Hoi, Kam Hon, Reddy, Sai T., Carroll, Sean M., Ge, Xin, Rogosch, Tobias, Zemlin, Michael, Shultz, Leonard D., Ellington, Andrew D., VanDenBerg, Carla L., Georgiou, George
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338711/
https://ncbi.nlm.nih.gov/pubmed/22558161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035497
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