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Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvature.
The influence of DNA structure on topoisomerase I-DNA interaction has been investigated using a high affinity binding site and mutant derivatives thereof. Parallel determinations of complex formation and helix structure in the absence of superhelical stress suggest that the interaction is intensifie...
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| Main Authors: | , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1991
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC333848/ https://ncbi.nlm.nih.gov/pubmed/1851553 |
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