Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells

Phage display screening allows the study of functional protein–protein interactions at the cell surface, but investigating intracellular organelles remains a challenge. Here we introduce internalizing-phage libraries to identify clones that enter mammalian cells through a receptor-independent mechan...

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Bibliografiske detaljer
Main Authors: Rangel, Roberto, Guzman-Rojas, Liliana, le Roux, Lucia G., Staquicini, Fernanda I., Hosoya, Hitomi, Barbu, E. Magda, Ozawa, Michael G., Nie, Jing, Jr, Kenneth Dunner, Langley, Robert R., Sage, E. Helene, Koivunen, Erkki, Gelovani, Juri G., Lobb, Roy R., Sidman, Richard L., Pasqualini, Renata, Arap, Wadih
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337985/
https://ncbi.nlm.nih.gov/pubmed/22510693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1773
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