Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

The management of CNS tumors is limited by the blood-brain barrier (BBB), a vascular interface that restricts the passage of most molecules from the blood into the brain. Here we show that phage particles targeted with certain ligand motifs selected in vivo from a combinatorial peptide library can c...

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Detalhes bibliográficos
Main Authors: Staquicini, Fernanda I., Ozawa, Michael G., Moya, Catherine A., Driessen, Wouter H.P., Barbu, E. Magda, Nishimori, Hiroyuki, Soghomonyan, Suren, Flores, Leo G., Liang, Xiaowen, Paolillo, Vincenzo, Alauddin, Mian M., Basilion, James P., Furnari, Frank B., Bogler, Oliver, Lang, Frederick F., Aldape, Kenneth D., Fuller, Gregory N., Höök, Magnus, Gelovani, Juri G., Sidman, Richard L., Cavenee, Webster K., Pasqualini, Renata, Arap, Wadih
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007161/
https://ncbi.nlm.nih.gov/pubmed/21183793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44798
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