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A microRNA circuit mediates Transforming Growth Factor-ß1 autoregulation in renal glomerular mesangial cells
Enhanced transforming growth factor-β1 (TGF-β1) expression in renal cells promotes fibrosis and hypertrophy during the progression of diabetic nephropathy. The TGF-β1 promoter is positively controlled by the E-box regulators, Upstream Stimulatory Factors (USFs), in response to diabetic (high glucose...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337779/ https://ncbi.nlm.nih.gov/pubmed/21389977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2011.43 |
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