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A microRNA circuit mediates Transforming Growth Factor-ß1 autoregulation in renal glomerular mesangial cells

Enhanced transforming growth factor-β1 (TGF-β1) expression in renal cells promotes fibrosis and hypertrophy during the progression of diabetic nephropathy. The TGF-β1 promoter is positively controlled by the E-box regulators, Upstream Stimulatory Factors (USFs), in response to diabetic (high glucose...

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Main Authors: Kato, Mitsuo, Arce, Laura, Wang, Mei, Putta, Sumanth, Lanting, Linda, Natarajan, Rama
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337779/
https://ncbi.nlm.nih.gov/pubmed/21389977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2011.43
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