Midostaurin does not prolong cardiac repolarization defined in a thorough electrocardiogram trial in healthy volunteers

PURPOSE: Midostaurin (PKC412) is a multitargeted tyrosine kinase inhibitor of FMS-like tyrosine kinase 3 receptor (FLT3), c-KIT, and other receptors. Midostaurin is active in patients with acute myeloid leukemia and systemic mastocytosis. Although no substantive risk for cardiac abnormalities has be...

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Hauptverfasser: del Corral, Adam, Dutreix, Catherine, Huntsman-Labed, Alice, Lorenzo, Sebastien, Morganroth, Joel, Harrell, Robert, Wang, Yanfeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337405/
https://ncbi.nlm.nih.gov/pubmed/22294470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1825-y
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