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The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice
In order to prime T cells, DCs integrate signals emanating directly from pathogens and from their noxious action on the host. DNGR-1 (CLEC9A) is a DC-restricted receptor that detects dead cells. Therefore, we investigated the possibility that DNGR-1 affects immunity to cytopathic viruses. DNGR-1 was...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3336985/ https://ncbi.nlm.nih.gov/pubmed/22505455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60660 |
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