The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs against dead cell antigens in mice. It is currently unknown how DNGR-1 couples dead cell recognition to cross-priming. Here we found that DNGR-1 did not mediate DC activation by dead cells but rather diverted necrot...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Zelenay, Santiago, Keller, Anna M., Whitney, Paul G., Schraml, Barbara U., Deddouche, Safia, Rogers, Neil C., Schulz, Oliver, Sancho, David, Reis e Sousa, Caetano
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336984/
https://ncbi.nlm.nih.gov/pubmed/22505458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60644
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky