The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs against dead cell antigens in mice. It is currently unknown how DNGR-1 couples dead cell recognition to cross-priming. Here we found that DNGR-1 did not mediate DC activation by dead cells but rather diverted necrot...

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Bibliographic Details
Main Authors: Zelenay, Santiago, Keller, Anna M., Whitney, Paul G., Schraml, Barbara U., Deddouche, Safia, Rogers, Neil C., Schulz, Oliver, Sancho, David, Reis e Sousa, Caetano
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336984/
https://ncbi.nlm.nih.gov/pubmed/22505458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60644
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