The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead cell-associated antigens

Type 1 conventional dendritic cells (cDC1s) are necessary for cross-presentation (XP) of many viral and tumor antigens to CD8(+) T cells. cDC1s can be identified in mice and humans by high expression of DNGR-1 (a.k.a. CLEC9A), a receptor that binds dead cell debris and facilitates XP of corpse-assoc...

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Publicado en:Nat Immunol
Autores principales: Canton, Johnathan, Blees, Hanna, Henry, Conor M., Buck, Michael D., Schulz, Oliver, Rogers, Neil C., Childs, Eleanor, Zelenay, Santiago, Rhys, Hefin, Domart, Marie-Charlotte, Collinson, Lucy, Alloatti, Andres, Ellison, Cara J., Amigorena, Sebastian, Papayannopoulos, Venizelos, Thomas, David C., Randow, Felix, Reis e Sousa, Caetano
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116638/
https://ncbi.nlm.nih.gov/pubmed/33349708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-00824-x
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