Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic cells (cDC1s) is thought to underlie priming of anti-cancer CD8(+) T cells. cDC1 express high levels of DNGR-1 (a.k.a. CLEC9A), a receptor that binds to F-actin exposed by dead cell debris and promotes cross-presen...

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Publicado no:Cell
Main Authors: Giampazolias, Evangelos, Schulz, Oliver, Lim, Kok Haw Jonathan, Rogers, Neil C., Chakravarty, Probir, Srinivasan, Naren, Gordon, Oliver, Cardoso, Ana, Buck, Michael D., Poirier, Enzo Z., Canton, Johnathan, Zelenay, Santiago, Sammicheli, Stefano, Moncaut, Natalia, Varsani-Brown, Sunita, Rosewell, Ian, Reis e Sousa, Caetano
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320529/
https://ncbi.nlm.nih.gov/pubmed/34081922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.05.021
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