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Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration
Protein-folding occurs in several intracellular locations including the endoplasmic reticulum and mitochondria. In normal conditions there is a balance between the levels of unfolded proteins and protein folding machinery. Disruption of homeostasis and an accumulation of unfolded proteins trigger st...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3336107/ https://ncbi.nlm.nih.gov/pubmed/22539924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2012.00005 |
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