Vacuolating Cytotoxin and Variants in Atg16L1 that Disrupt Autophagy Promote Helicobacter pylori Infection in Humans

BACKGROUND & AIMS: The Helicobacter pylori toxin vacuolating cytotoxin (VacA) promotes gastric colonization and its presence (VacA+) is associated with more-severe disease. The exact mechanisms by which VacA contributes to infection are unclear. We previously found that limited exposure to VacA...

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Main Authors: Raju, D, Hussey, S, Ang, M, Terebiznik, M.R., Sibony, M, Galindo-Mata, E, Gupta, V, Blanke, S.R., Delgado, A, Romero-Gallo, J, Ramjeet, M, Mascarenhas, H, Peek, R.M., Correa, P, Streutker, C, Hold, G, Kunstmann, E, Yoshimori, T, Silverberg, M. S., Girardin, S.E., Philpott, D.J., El Omar, E, Jones, N.L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336037/
https://ncbi.nlm.nih.gov/pubmed/22333951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.01.043
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