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Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts
TopBP1 is critical for both DNA replication and checkpoint regulation in vertebrate cells. In this study, we have identified Rif1 as a binding partner of TopBP1 in Xenopus egg extracts. In addition, Rif1 also interacts with both ATM and the Mre11-Rad50-Nbs1 (MRN) complex, which are key regulators of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335920/ https://ncbi.nlm.nih.gov/pubmed/22391207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.6.19636 |
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