Using the “reverse Warburg effect” to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers

We have recently proposed a new model of cancer metabolism to explain the role of aerobic glycolysis and L-lactate production in fueling tumor growth and metastasis. In this model, cancer cells secrete hydrogen peroxide (H(2)O(2)), initiating oxidative stress and aerobic glycolysis in the tumor stro...

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Main Authors: Witkiewicz, Agnieszka K, Whitaker-Menezes, Diana, Dasgupta, Abhijit, Philp, Nancy J, Lin, Zhao, Gandara, Ricardo, Sneddon, Sharon, Martinez-Outschoorn, Ubaldo E, Sotgia, Federica, Lisanti, Michael P
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335917/
https://ncbi.nlm.nih.gov/pubmed/22313602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.6.19530
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