A coding variant in CR1 interacts with APOE-ɛ4 to influence cognitive decline

Complement receptor 1 (CR1) is an Alzheimer's disease (AD) susceptibility locus that also influences AD-related traits such as episodic memory decline and neuritic amyloid plaque deposition. We implemented a functional fine-mapping approach, leveraging intermediate phenotypes to identify functi...

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Detalhes bibliográficos
Main Authors: Keenan, Brendan T., Shulman, Joshua M., Chibnik, Lori B., Raj, Towfique, Tran, Dong, Sabuncu, Mert R., Allen, April N., Corneveaux, Jason J., Hardy, John A., Huentelman, Matthew J., Lemere, Cynthia A., Myers, Amanda J., Nicholson-Weller, Anne, Reiman, Eric M., Evans, Denis A., Bennett, David A., De Jager, Philip L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335317/
https://ncbi.nlm.nih.gov/pubmed/22343410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds054
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