A coding variant in CR1 interacts with APOE-ɛ4 to influence cognitive decline

Complement receptor 1 (CR1) is an Alzheimer's disease (AD) susceptibility locus that also influences AD-related traits such as episodic memory decline and neuritic amyloid plaque deposition. We implemented a functional fine-mapping approach, leveraging intermediate phenotypes to identify functi...

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Bibliografische gegevens
Hoofdauteurs: Keenan, Brendan T., Shulman, Joshua M., Chibnik, Lori B., Raj, Towfique, Tran, Dong, Sabuncu, Mert R., Allen, April N., Corneveaux, Jason J., Hardy, John A., Huentelman, Matthew J., Lemere, Cynthia A., Myers, Amanda J., Nicholson-Weller, Anne, Reiman, Eric M., Evans, Denis A., Bennett, David A., De Jager, Philip L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2012
Onderwerpen:
Association Studies Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335317/
https://ncbi.nlm.nih.gov/pubmed/22343410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds054
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