A coding variant in CR1 interacts with APOE-ɛ4 to influence cognitive decline

Complement receptor 1 (CR1) is an Alzheimer's disease (AD) susceptibility locus that also influences AD-related traits such as episodic memory decline and neuritic amyloid plaque deposition. We implemented a functional fine-mapping approach, leveraging intermediate phenotypes to identify functi...

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Библиографические подробности
Главные авторы: Keenan, Brendan T., Shulman, Joshua M., Chibnik, Lori B., Raj, Towfique, Tran, Dong, Sabuncu, Mert R., Allen, April N., Corneveaux, Jason J., Hardy, John A., Huentelman, Matthew J., Lemere, Cynthia A., Myers, Amanda J., Nicholson-Weller, Anne, Reiman, Eric M., Evans, Denis A., Bennett, David A., De Jager, Philip L.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
Association Studies Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335317/
https://ncbi.nlm.nih.gov/pubmed/22343410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds054
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